Endocrine Abstracts

Irritable bowel syndrome (IBS) which is very common is characterized by chronic intermittent symptoms, including recurrent abdominal pain, altered frequency of defecation, stool urgency and excess flatus. Widespread symptoms associated with IBS are abnormal defecation and abdominal pain, both of which can be exacerbated by psychogenic stress. IBS is one of the stress-related bodily disorders and it has been suggested that patients with IBS may exhibit disturbances in the hypot...

PTTG is tumourigenic in vivo and transactivates fibroblast growth factor-2 (FGF-2). We have previously identified expression of PTTG and FGF-2 as potential prognostic indicators for differentiated thyroid cancer. Critical to PTTG function is a double PXXP motif, forming a putative SH3-interacting domain. We employed cDNA array approaches to identify further genes regulated via this region. MCF12A cells were transiently transfected with vector-only (VO) control, wild-type (WT)-...